Uses
Obsessive-Compulsive Disorder (OCD)
Management of OCD; reduces but does not eliminate obsessions and compulsions.
Bulimia Nervosa
Has been used in the management of bulimia nervosa†.
Dosage and Administration
General
- Allow at least 2 weeks to elapse between discontinuance of therapy with an MAO inhibitor and initiation of fluvoxamine therapy and vice versa.
- Monitor for possible worsening of depression, suicidality, or unusual changes in behavior, especially at the beginning of therapy or during periods of dosage adjustments. (See Worsening of Depression and Suicidality Risk under Cautions.)
- Sustained therapy may be required; monitor periodically for need for continued therapy.
- Avoid abrupt discontinuance of therapy. To avoid withdrawal reactions, taper dosage gradually. (See Worsening of Depression and Suicidality Risk and also see Withdrawal of Therapy under Cautions.)
- Consider cautiously tapering dosage during third trimester of pregnancy prior to delivery. (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
Administration
Oral Administration
Administer orally once or twice daily without regard to meals.
Administer dosages ≤100 mg daily in adults or ≤50 mg in pediatric patients as a single daily dose at bedtime; higher dosages generally are given as 2 divided doses, either as equally divided doses or as unequal doses with the larger dose given at bedtime.
Dosage
Available as fluvoxamine maleate; dosage is expressed in terms of the salt.
Pediatric Patients
OCD
Oral
Children >8 years of age: Initially, 25 mg at bedtime. Increase dosages in 25-mg increments every 4–7 days, as tolerated, until maximum therapeutic benefit is achieved or up to a maximum dosage of 200 mg daily in children ≤11 years of age or 300 mg daily in adolescents ≥12 years of age. Girls ≤11 years of age may require lower dosages.
Optimum duration of therapy not established; may require several months of sustained drug therapy. Use the lowest possible dosage and periodically reassess need for continued therapy.
Adults
OCD
Oral
Initially, 50 mg at bedtime. Increase dosages in 50-mg increments every 4–7 days, as tolerated, until maximum therapeutic benefit is achieved or up to a maximum dosage of 300 mg daily.
Optimum duration of therapy not established; may require several months of sustained drug therapy. Use the lowest possible dosage and periodically reassess need for continued therapy.
Prescribing Limits
Pediatric Patients
OCD
Oral
Children ≤11 years of age: Maximum 200 mg daily.
Adolescents ≥12 years of age: Maximum 300 mg daily.
Adults
OCD
Oral
Maximum 300 mg daily.
Special Populations
Dosage in Hepatic Impairment
OCD
Oral
Use lower initial dosage and titrate dosage slowly.
Dosage in Renal Impairment
OCD
Oral
Limited evidence indicates that dosage modification is not necessary.
Geriatric Patients
Initially, 25 mg daily; titrate dosage slowly.
Print
Email
FDA Alerts
Media Gallery
Medicare's drug plans are subsidized by the US federal government and offered through insurers.
