Uses
Periodontitis
Used orally as an adjunct to scaling and root planing to promote attachment-level gain and to reduce pocket depth in adults with periodontitis.
Used subgingivally in treatment of chronic periodontitis in adults to reduce pocket depth, gain clinical attachment level, and reduce bleeding associated with probing.
Dosage and Administration
Administration
Oral Administration
Administered orally as 20-mg tablets for adjunctive treatment of periodontitis.
Administer doses in the morning and evening and at least 1 hour prior to or 2 hours after meals.
Give with adequate amounts of fluids to reduce risk of esophageal irritation and ulceration.
Subgingival Administration
Administered subgingivally (as an extended-release preparation containing the drug incorporated into a bioresorbable polymer) into periodontal pockets by an oral health-care professional.
Each pair of syringes is intended for single use only.
Administration does not require local anesthesia.
Preparation does not have to be manually removed; preparation solidifies upon contact with gingival crevicular fluid and is bioabsorbed or expelled naturally.
Reconstitution
Mix contents of the 2 paired syringes (liquid polymeric delivery system [syringe A]; doxycycline hyclate powder [syringe B]) together prior to administration. Remove syringes from the refrigerator at least 15 minutes prior to mixing.
Couple syringes together and inject contents of syringe A into syringe B and then back into syringe A to complete 1 mixing cycle. Perform 100 mixing cycles (approximately 1 mixing cycle per second) prior to administration.
If not administered immediately, store coupled syringes in resealable pouch at room temperature for up to 3 days; an additional 10 mixing cycles is required just prior to administration.
After mixing, hold coupled syringes vertically with syringe A (indicated by a purple stripe) at the bottom. Pull down on the plunger of syringe A and allow contents to flow down the barrel for several seconds into syringe A. Uncouple syringes and attach the blunt cannula supplied in the package to syringe A prior to administration. Bend cannula to resemble a periodontal probe.
Subgingival Administration Technique
Using the syringe with bent cannula, position tip of cannula near the base of the periodontal pocket and administer preparation into the pocket until the formulation reaches the top of the gingival margin.
After administration is completed, withdraw cannula from the pocket and cover pocket with periodontal dressing or dental adhesive.
Dosage
Available as doxycycline hyclate; dosage expressed in terms of doxycycline; 50 mg of doxycycline hyclate equivalent to 42.5 mg of doxycycline.
Adults
Periodontitis
Oral
20 mg every 12 hours.
Safety of >12 months of treatment and efficacy of >9 months of treatment have not been established.
Subgingival
Dosage varies depending on the size, shape, and number of periodontal pockets treated. May repeat treatment 4 months after the initial treatment.
Print
Email
Media Gallery
Drug Info Tools
Medicare's drug plans are subsidized by the US federal government and offered through insurers.
