Actions
- Inhibits basal and stimulated gastric acid secretion.
- Competitively inhibits histamine at parietal cell H2 receptors.
- Weak antiandrogenic effect.
Advice to Patients
- Importance of patients informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs.
- Importance of taking antacids on an empty stomach 1 hour before or 1 hour after oral administration of cimetidine, or 1 hour after the drug is taken with food, but not at same time as oral cimetidine.
- Importance of women informing clinician if they are or plan to become pregnant or plan to breast-feed.
- Before self-medication, importance of consulting clinician if taking warfarin, theophylline, or phenytoin.
- Importance of following dosage instructions when cimetidine is administered for self-medication, unless otherwise directed by a clinician.
- Importance of promptly informing clinician of persistent abdominal pain or difficulty swallowing.
- Importance of informing patients of other important precautionary information. (See Cautions.)
Preparations
Cimetidine
| Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|
| Oral | Solution | 300 mg/mL* |
Cimetidine Hydrochloride Oral Solution | Actavis, Duramed, Endo, Hi-Tech, Morton Grove, Pharmaceutical Associates, Teva |
| | |
Tagamet® (with parabens, povidone, and propylene glycol) | GlaxoSmithKline |
| Tablets, film-coated | 200 mg* |
Tagamet® HB 200 | GlaxoSmithKline |
| | |
Tagamet® HB (with povidone) | GlaxoSmithKline |
| | 300 mg* |
Tagamet® (with povidone and propylene glycol) | GlaxoSmithKline |
| | 400 mg* |
Tagamet® Tiltab® (with povidone and propylene glycol) | GlaxoSmithKline |
| | 800 mg* |
Tagamet® Tiltab® (with povidone and propylene glycol; scored) | GlaxoSmithKline |
| * available generically |
Cimetidine Hydrochloride
| Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|
| Oral | Solution | 300 mg (of cimetidine) per 5 mL* |
Tagamet® HCl (with alcohol 2.8% parabens and propylene glycol) | GlaxoSmithKline |
| Parenteral | Injection | 150 mg (of cimetidine) per mL |
Cimetidine Hydrochloride Injection | Endo, Hospira, Sicor |
| Injection, for IV infusion only | 150 mg (of cimetidine) per mL |
Cimetidine Hydrochloride ADD-Vantage® | Hospira |
| * available generically |
Cimetidine Hydrochloride in Sodium Chloride
| Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|
| Parenteral | Injection, for IV infusion only | 6 mg (of cimetidine) per mL (300, 900, or 1200 mg) in 0.9% Sodium Chloride |
Cimetidine HCl in 0.9% Sodium Chloride Injection (available in flexible plastic container) | Hospira |
| | 6 mg (of cimetidine) per mL (300 mg) in 0.9% Sodium Chloride |
Comparative Pricing
This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
| Cimetidine 200MG Tablets | MYLAN | 30/$19.99 or 90/$39.99 |
| Cimetidine 300MG Tablets | IVAX PHARMACEUTICALS, INC. | 90/$16 or 180/$18 |
| Cimetidine 400MG Tablets | IVAX PHARMACEUTICALS, INC. | 90/$17 or 180/$20 |
| Cimetidine 800MG Tablets | TEVA PHARMACEUTICALS USA | 30/$17.99 or 90/$37.98 |
| Cimetidine HCl 300MG/5ML Solution | TEVA PHARMACEUTICALS USA | 237/$35.55 or 711/$106.65 |
| Tagamet 300MG Tablets | GLAXO SMITH KLINE | 60/$71.8 or 180/$207.05 |
| Tagamet 400MG Tablets | GLAXO SMITH KLINE | 60/$114.89 or 180/$331.52 |
| Tagamet HB 200MG Tablets | GLAXO CONSUMER HEALTHCARE L.P. | 50/$13.56 or 150/$40.68 |
AHFS Drug Information. © Copyright, 1959-2008, Selected Revisions August 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
† Use is not currently included in the labeling approved by the US Food and Drug Administration.
Remember, keep this and all other medicines out of the reach of children,
never share your medicines with others, and use this medication only for the indication prescribed.
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