| Clcr (mL/min per 1.73 m2) | Induction Dose | Maintenance Dosage |
|---|---|---|
| 25–50 | 1 g | 500 mg every 12 hours |
| 10–25 | 1 g | 500 mg every 24 hours |
| 0–10 | 1 g | 500 mg every 36 hours |
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Treatment of pharyngitis and tonsillitis caused by Streptococcus pyogenes (group A β-hemolytic streptococci). Generally effective in eradicating S. pyogenes from the nasopharynx, but efficacy in prevention of subsequent rheumatic fever has not been established to date.
CDC, AAP, IDSA, AHA, and others recommend oral penicillin V or IM penicillin G benzathine as treatments of choice; oral cephalosporins and oral macrolides considered alternatives. Amoxicillin sometimes used instead of penicillin V, especially for young children.
Treatment of mild to moderate skin and skin structure infections caused by susceptible staphylococci or streptococci.
Treatment of mild to moderate UTIs, include acute prostatitis, caused by susceptible Escherichia coli, Klebsiella, or Proteus mirabilis.
Alternative for prevention of α-hemolytic (viridans group) streptococcal endocarditis† in penicillin-allergic individuals undergoing certain dental or upper respiratory tract procedures who have cardiac conditions that put them at highest risk. Should not be used in those with immediate-type penicillin hypersensitivity (see Cross-hypersensitivity under Cautions).
When selecting anti-infectives for prophylaxis of bacterial endocarditis, consult most recent AHA recommendations for specific information on which cardiac conditions are associated with highest risk of endocarditis and which procedures require prophylaxis.
Administer orally.
May be given without regard to meals; administration with food may minimize adverse GI effects.
Available as the monohydrate; dosage expressed as cefadroxil.
AAP recommends 30 mg/kg daily in 2 equally divided doses for treatment of mild or moderately severe infections in children ≥1 month of age. AAP states the drug is inappropriate for treatment of severe infections.
30 mg/kg daily given as a single dose or in 2 equally divided doses for ≥10 days.
30 mg/kg daily given as a single dose or in 2 equally divided doses.
30 mg/kg daily given in 2 equally divided doses.
30 mg/kg daily given in 2 equally divided doses.
50 mg/kg (up to 2 g) as a single dose given 1 hour prior to the procedure.†
1 g daily given as a single dose or in 2 divided doses for 10 days.
1 g daily given as a single dose or in 2 divided doses.
1 or 2 g daily given as a single dose or in 2 divided doses.
2 g daily given in 2 divided doses.
2 g as a single dose given 1 hour prior to the procedure.†
Dosage adjustments required if Clcr ≤50 mL/minute per 1.73 m2. Use an initial 1-g induction dose followed by 500-mg maintenance doses given at intervals based on the degree of renal impairment. (See Table.)
| Clcr (mL/min per 1.73 m2) | Induction Dose | Maintenance Dosage |
|---|---|---|
| 25–50 | 1 g | 500 mg every 12 hours |
| 10–25 | 1 g | 500 mg every 24 hours |
| 0–10 | 1 g | 500 mg every 36 hours |
No dosage adjustments except those related to renal impairment. Cautious dosage selection because of age-related decreases in renal function. (See Renal Impairment under Dosage and Administration.)
Last Updated: March 01, 2008Related Learning Centers |