Lack of intrinsic factor

Definition

Intrinsic factor is a natural substance normally found in the stomach. You need this substance to digest vitamin B12.

Lack of intrinsic factor leads to pernicious anemia and vitamin B12 deficiency.

Babies that are born without intrinsic factor cannot properly absorb vitamin B12 starting around 6 months of age. Children with the juvenile type of lack of intrinsic factor tends to show signs and symptoms after age 10.

Alternative Names

Intrinsic factor - lack of

References

Antony AC. Megaloblastic anemias. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 170.