Gumma

Definition

A gumma is a soft, tumor-like growth of the tissues (granuloma).

Causes, incidence, and risk factors

A gumma is caused by syphilis. It appears during late-stage tertiary syphilis. It usually contains a mass of dead and swollen fiber-like tissue, and occurs most often in the liver. It also can occur in the:

• Bone
• Brain
• Heart
• Skin
• Testis
• Eyes

Similar-looking sores sometimes occur with tuberculosis.

References

Tramont EC. Treponema pallidum (Syphilis). In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 6th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2005:chap 235.

Eckert LO, Lentz GM. Infections of the lower genital tract: vulva, vagina, cervix, toxic shock syndrome, HIV infections. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. Comprehensive Gynecology. 5th ed. Philadelphia, Pa: Mosby Elsevier; 2007:chap 22.

Centers for Disease Control and Prevention, Workowski KA, Berman SM. Diseases characterized by genital ulcers. Sexually transmitted diseases treatment guidelines 2006. MMWR Morb Mortal Wkly Rep. 2006 Aug 4;55(RR-11):14-30.