Chronic inflammatory polyneuropathy Health Article

Definition

Chronic inflammatory polyneuropathy is nerve swelling and irritation (inflammation) that leads to a loss of movement or sensation.

Alternative Names

Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory demyelinating polyneuropathy

Causes, incidence, and risk factors

Chronic inflammatory polyneuropathy is a common type of damage to nerves outside the brain or spinal cord (peripheral neuropathy). Polyneuropathy means several nerves are involved. It usually affects both sides of the body the same amount.

The cause of chronic inflammatory polyneuropathy is an abnormal immune response. The specific triggers vary. In many cases, the cause is unknown.

It may occur with other conditions, such as:

• Blood cell abnormalities
• Chronic active hepatitis
• HIV
• Inflammatory bowel disease
• Lupus erythematosus

Guillain-Barre syndrome is a form of inflammatory polyneuropathy that lasts for a shorter time.

Symptoms

• Difficulty walking
• Difficulty using the arms and hands or legs and feet
• Facial weakness
• Sensation changes (usually of the arms and hands or legs and feet)
  • Numbness or decreased sensation
  • Pain, burning, tingling, or other abnormal sensations
• Weakness, usually in the arms and hands or legs and feet

Other symptoms that can occur with this disease:

• Abnormal movement
• Bowel or bladder problems
• Breathing difficulty
• Fatigue
• Hoarseness or changing voice
• Joint pain
• Loss of function or feeling in the muscles
• Muscle atrophy
• Muscle contractions
• Paralysis of the face
• Speech impairment
• Swallowing difficulty
• Uncoordinated movement

Signs and tests

An exam shows:

• Loss of muscle mass
• No reflexes
• Paralysis
• Problems with the senses
• Muscle weakness
• Sensation problems on both sides of the body, moving from the arms and legs to the center of the body

Tests may include:

• Electromyography (EMG)
• Nerve conduction tests
• Nerve biopsy
• Spinal tap

Which other tests are done depends on the suspected cause of the condition, and may include x-rays, imaging scans, and blood tests.